Supporting drug substance and drug product impurity characterisation and identification
Performing protein sequence and post translational modification identification, including glycosylation analysis.
Supporting drug substance and drug product process development by performing characterisation of process intermediates
Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis
Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
Contribute to writing study protocols and reports.
Independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others.
Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance.
Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department. May also act as a mentor to other colleagues, sharing scientific knowledge. Providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the department.
Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this.
Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively.
Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners.
Adhere to safe working practices in laboratories according to Immunocore EHS policies.

Experience & knowledge
Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
Experience of glycosylation analysis of recombinant proteins or antibodies.
Independently coordinated extensive testing of protein biomolecules.
Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
Understanding of expected post-translational modifications in biological systems.
Worked in a bench-based biopharmaceutical laboratory environment.
Established as an expert amongst peers in one or more of the following areas:
Experienced in assay development
Familiar with biopharmaceutical stability study principles and interpretation thereof
Worked and contributed actively in a diverse team environment
Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change
Presented detailed scientific findings and papers to internal and external audiences
Experience of glycosylation analysis of recombinant proteins or antibodies
Experience with late stage/commercial biopharmaceutical assay development and characterisation
Familiar with the principles of Good Manufacturing Practise (GMP)
Presented at external conferences
Led a small project team, formally or informally, through a change in practice including project management
Understanding of analytical requirements to support materials for use in clinical trials
Essential: BSc. Or MSc. in biochemistry, biotechnology or related discipline
Desirable: PhD in related discipline

Senior Scientist I - Characterisation | CMC - Oxford Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

42 Immunocore Ltd jobs in England & Wales