Senior Scientist II / Associate Principal Scientist - DMPK

organisation of ~70 scientists, you will play a key role in generating high-quality experimental data and translating DMPK insights to guide compound optimisation and candidate selection. You will work closely on multiple projects with medicinal chemistry and biology teams both at Vernalis and with our collaborators, as well as manage and direct work carried out at external CROs. Key Responsibilities Design, execute, and interpret in vitro ADME studies Develop, optimise, and apply LC-MS/MS analytical methods to support in vitro and in vivo studies Design and oversee in vivo studies via CROs, including study design, dose selection, and sampling strategy Perform pharmacokinetic analysis and data interpretation Conduct and lead metabolite identification studies (MetID) with structural elucidation to inform medicinal chemistry design Maintain and develop internal DMPK laboratory capabilities and workflows Identify and mitigate key DMPK risks Contribute to multidisciplinary project teams and

decision-making Knowledge & Experience Essential: Strong hands-on experience in small molecule discovery DMPK In vitro ADME assay execution and interpretation LC-MS/MS use and troubleshooting ability Design and interpretation of in vivo PK studies Proven ability to integrate data and inform project decisions Desirable: Familiarity with PK/PD modelling tools Metabolite identification (MetID) Aseptic cell culture technique Ability to design project-specific screening cascades to reflect current needs Experience supporting decision making for candidate selection Experience working with external collaborators and CROs Skills and competencies Essential: Strong hands-on experimental capability and troubleshooting skills Excellent data analysis and scientific interpretation Ability to translate data into clear, actionable insights Effective communication across multidisciplinary teams Strong organisation and time management skills Ability to balance lab work with project delivery Ability to
influence project direction Desirable: Leadership and mentoring experience Demonstratable ability to innovate in the speciality of DMPK Education & Qualifications Essential: PhD (or equivalent) in relevant field and several years of DMPK experience in a professional drug discovery related setting Why Vernalis? At Vernalis you will be part of "One Team" working in a friendly and collaborative office. We offer a comprehensive range of benefits including generous pension contributions, private healthcare cover, 26 days annual leave, plus bank holidays, holiday purchase scheme, flexitime, discretionary bonus, employee assistance programme and enhanced family leave policies. Vernalis Research is committed to promoting a diverse and inclusive community - a place where we can all be ourselves and succeed on merit. #J-18808-Ljbffr