Principal Scientist (Mechanistic Pharmacology)

Our strategy sets out to bring deeper mechanistic understanding at the molecular and cellular level to all stages of projects, from idea to pre-clinical candidate. This role is focussed on designing, developing and running of cellular assays to identify, profile and characterise the SAR/SKR of small molecules therapeutics, as well as the bespoke characterisation of their mechanism of action to inform dose-prediction and clinical efficacy. As a Principal Scientist within the Cellular Pharmacology team, you will be a senior scientific leader, driving project strategy, influencing decision-making, and helping to shape the future direction of the group. The successful candidate will champion innovative ways of working by staying at the forefront of advances in cellular pharmacology techniques and applying emerging techniques to drug discovery challenges. We actively encourage colleagues to share and celebrate our science through conference attendance, poster and oral presentations, and publications. This role offers the opportunity to play an integral part in the Cancer Research Horizon Drug Discovery, working closely with industry and academic partners to progress novel cancer targets towards patient benefit.

We are looking for a strategic and collaborative scientific leader who can shape project direction, influence decision-making, and drive high-quality science. You will be passionate about developing others, fostering a culture of excellence, and delivering impactful outcomes in a fast-paced drug discovery environment. You will also bring:

• A BSc, MSc or PhD in biological science; relevant experience can be substituted for education
• Significant experience in a drug discovery environment of characterising targets and their modulation by small molecules through quantitative cellular pharmacology, including a kinetic context
• Demonstrated theoretical and practical understanding of pharmacology and drug-target interactions
• Expertise in assay development across a range of quantitative cell-based assay technologies, with the ability to input across multiple projects both at the lab bench and intellectually
• Significant experience of using microscopy/imaging in a quantitative pharmacology setting would be highly desirable
• Demonstrated scientific leadership skills with ability to give strategic direction
• Experience of managing the performance and development of line reports
• Credible external reputation, as evidenced though publication, presentation at key conferences, and a strong personal network
Our organisation values are designed to guide all that we do. Bold: Act with ambition, courage and determination Credible: Act with rigour and professionalism Human: Act to have a positive impact on people Together: Act inclusively and collaboratively We're looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.

At Cancer Research UK, we exist to beat cancer. We are looking for a talented scientific leader with significant experience in pre-clinical cellular pharmacology within an industrial drug discovery setting to join our Mechanistic Pharmacology group as a Principal Scientist. As the world's biggest medical research charity, we've helped bring fourteen new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster. Cancer Research Horizons (CRH) is CRUK's internal translation engine. CRUK's established drug discovery teams operate under one organisation and leadership team. Our unique combination of cancer biology expertise and access to CRUK's world-class academic network, coupled with cutting edge technology platforms and clinical expertise enables us to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success. Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, and Newcastle University, Cancer Research Horizons employs ~180 staff from both industrial and academic backgrounds.