Postdoctoral Researcher in Human Disease Modelling

The project combines iPSC and organoid culture with high-dimensional readouts including multi-parameter flow cytometry, single-cell and spatial transcriptomics, and quantitative imaging. Working closely with other postdoctoral researchers and PhD students, the post-holder will deliver translational projects that characterise laboratory-engineered, iPSC-derived immune cells as they mature, and apply these cells within organoid and multi-organoid chip platforms to test and refine candidate therapies. The project combines iPSC and organoid culture with high-dimensional readouts including multi-parameter flow cytometry, single-cell and spatial transcriptomics, and quantitative imaging.

You will hold, or be close to completion of, a PhD/DPhil in a relevant area of the life sciences and have a strong publication record. You will bring broad experience in molecular and cellular biology, including standard techniques for nucleic acid and protein analysis, together with demonstrable hands-on experience in mammalian cell culture and multi-parameter flow cytometry. You will be able to manage your own research, work collaboratively within a multidisciplinary team, and communicate your findings clearly. Experience with iPSC culture, organoid or other 3D model systems, organ-on-chip or microfluidic platforms, and single-cell or spatial omics technologies is desirable. A background in immunology-particularly in haematopoietic, myeloid, or innate immune cell biology-as well as developmental biology, especially haematopoiesis and early lymphopoiesis, would be advantageous.
The post is available on a full-time basis and is fixed-term for 2 years, funded by the Wellcome.

Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford