Postdoctoral Research Scientist

Department of Physiology, Anatomy & Genetics, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3QU, We are seeking a Postdoctoral Research Scientist to join our Laboratory of Molecular Neurodegeneration at the Department of Physiology, Anatomy and Genetics, University of Oxford. The ideal candidate will be a highly motivated and skilled cellular neurophysiologist with experience in the differentiation and analysis of human Parkinson's and control iPSC lines into striatal, dopaminergic and cortical neurons in mono-culture and microfluidic tri-culture. In this role, you will be responsible for the differentiation of human Parkinson's and control iPSC lines into striatal, dopaminergic and cortical neurons in mono-culture and microfluidic tri-culture, assays of neuronal electrophysiology and calcium signalling, analysis of Parkinson's cellular phenotypes using high-content imaging in striatal, dopaminergic and cortical neurons, and in molecular cell biology and RNA-Seq single cell gene expression analysis. This post is available for 7 months from December 2026.,

• Differentiation of human iPSC lines into striatal, dopaminergic and cortical neurons in mono-culture and microfluidic tri-culture
• Assays of neuronal electrophysiology and calcium signalling
• Analysis of Parkinson's cellular phenotypes using high-content imaging in striatal, dopaminergic and cortical neurons
• Molecular cell biology and RNA-Seq single cell gene expression analysis
• Contributing to research development and publications
• Contribute ideas for new research projects and develop ideas for generating research income
• Manage own academic research and administrative activities involving small scale project management
• Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques
• Collaborate in the preparation of scientific reports and journal articles and present papers and posters
• Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate
  
  Hold or be near to completion of PhD or DPhil degree in neuroscience or cell/molecular biology, or equivalent.
• Hands-on expertise in the differentiation of human iPSC lines into striatal, dopaminergic and cortical neurons in mono-culture and microfluidic tri-culture
• Hands-on expertise in assays of neuronal electrophysiology and calcium signalling
• Hands-on expertise in analysis of Parkinson's cellular phenotypes using high-content imaging in striatal, dopaminergic and cortical neurons
• Hands-on expertise in molecular cell biology and RNA-Seq single cell gene expression analysis
• Ability to manage own academic research and associated activities
• Previous experience of contributing to publications/presentations
• Ability to contribute ideas for new research projects and research income generation
• Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings
• Experience of creating collaborative and inclusive environments with people from different backgrounds.
  
  At the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment.
  
  Your wellbeing at work matters, so we offer a range of family friendly and financial benefits including:
• An excellent contributory pension scheme
• 38 days annual leave
• A comprehensive range of childcare services
• Family leave schemes
• Cycle and electric car loan schemes
• Employee Assistance Programme
• Membership to a variety of social and sports clubs
• Discounted bus travel and Season Ticket travel loans