postdoctoral Research Associate (PDRA)

A postdoctoral Research Associate (PDRA) position is available on a full time basis for 12 months to contribute to the project: Development and Validation of a Multi-functional, Multi-purpose Quantitative Tool for Dermal Physiologically-Based Pharmacokinetic Modeling. Background: Topical drug products applied to the skin undergo substantial metamorphosis as they are rubbed into the application site: volatile excipients like water and alcohols evaporate, and drug and excipients absorb into the skin. The resultant residual film on the skin surface has quite different composition, structure and properties compared to the starting formulation that "came out of the tube". Predicting drug absorption during metamorphosis and from the residual phase is an unsolved challenge. This multi-institution collaborative grant funded by the US-FDA aims to expand the capabilities of an existing physiologically based pharmacokinetic (PBPK) model simulating drug skin absorption and disposition to incorporate the metamorphosis of topical products following skin application. The final aim is developing tools that predict the performance of topical medicines and support bio(in)equivalence decisions. This opportunity falls within an ongoing collaboration with the University of Reading, the Colorado School of Mines, the company Simulations Plus, and the FDA. Bath's contribution to this research involves primarily the generation of experimental data to guide the development of this enhanced PBPK model by formulating products and the characterization of their metamorphotic events and their kinetics. Specifically, this PDRA will contribute to the project by: (a) formulating series of drug-vehicle combinations chosen for their potential to inform about metamorphotic events and provide relevant data for modelling purposes, (b) characterizing formulations by measuring drug stability and solubility in selected vehicles (initial formulations and after metamorphosis) and performing other tests (e.g., pH, viscosity, microscopy) as needed, (c) investigating drug and excipients (as feasible/relevant) skin permeation and disposition, (d) in collaboration with other researchers, link permeation data to metamorphosis events and formulation properties; and (d) investigating the manner in which experimental data might be exploited by a PBPK model. This challenging, fast-pace work will involve extensive formulation, IVPT and solubility tests and thus, quantitative analysis by HPLC. A successful candidate will be experienced in these techniques and will independently and pro-actively develop HPLC methods and propose alternative analytical approaches and tools which may be informative for the research aims. A background on skin formulation and percutaneous permeation is required. The successful candidate will have demonstrated capacity for carrying independent research including provision of technical reports, scientific outputs and efficient data presenting and sharing with the extended grant team and funders. As a member of Research Stall at the University of Bath, you will be encouraged to take up a minimum of 1- days professional development pro rata per year. 1. Contribute to the choice of formulations which will be used to elucidate the metamorphosis process, and identify relevant, quality and other drug and formulation characteristics that can inform about the metamorphosis process and its impact on drug absorption. 2. Conduct IVPT experiments to characterise the drug and excipients (as feasible and relevant) in vitro permeation across the skin and their disposition in skin layers. This experiments may involve the starting product, the residual phase and intermediate transition phase (as relevant/feasible). 3. Conduct preformulation work such as solubility and stability studies and other tests (e.g., viscometry, pH) identified as relevant. 4. Develop and validate HPLC methods (or appropriate alternative analytical approaches) for the quantitative measurement of drugs and excipients. 5. Conduct data processing, analysis, and interpretation in collaboration with research partners and ensure prompt interactions within the team to advance the project. 6. Participate in monthly meetings with stakeholders (regulators, industry, research networks, as relevant). The PDRA will play a key role in these meetings presenting latest results and acquiring background information required for data interpretation and the planning of future steps. 7. Contribute to scientific outcomes (conference presentations, scientific articles) of the grant. 8. Together with other researchers, ensure that University of Bath policies, including but not limited to health and safety, research integrity guidelines and SOPs are observed.

The appointee to the position should understand, and have first-hand experience of the techniques used; (a) for characterizing the in vitro skin permeation and disposition of chemicals, (b) for determining solubility and stability of drugs in formulations and (c) for the quantitative analysis of drugs in biological media including HPLC. A good understanding of the pharmaceutical sciences underpinning drug delivery across biological barriers and the formulation and testing of topical drug products will be advantageous.

We're continually expanding our benefits package to better support you and enhance your experience with us and the below is just an example of some of the many great benefits we offer:

• Free counselling services through Health Assured
• Cycle to work scheme
• Electric vehicle salary sacrifice scheme
• Staff discount at Team Bath gym
• Staff discounts on postgraduate tuition fees
• Staff discount on language courses
• Generous employer contributory pension schemes
• Generous annual leave allowance with an additional 5 discretionary days so that you can enjoy a positive work life balance
• A wide range of personal and professional development opportunities including Apprenticeships, LinkedIn Learning and more
• Free entry to the Holburne Museum in Bath
• Local discounts and more
• A family-friendly workplace
• An excellent reward package that recognises the talents of our diverse workforce
• Relocation allowance
• Visa reimbursement and Interest-Free Loan to help with the cost of some immigration expenses
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