Clinical Research Fellow

Clinical Research Fellow- UCL/UCLH Institute of Neurology, Ataxia CentreApplications are invited for a Clinical Research Fellow in the Ataxia Centre, UCL/UCLH Department of Neuroscience and Neurogenetics, UCL Institute of Neurology, under the supervision of Prof Paola Giunti., The postholder will be an essential member of the research team at the Ataxia Centre, providing clinical and research input into the Centre's research programme into Ataxia and will work closely with the Principal Investigators (PIs), Clinical Research Fellows and Clinical Trials nurses. Their primary role will be as sub-investigator in clinical drug trial: A phase 1/2a, open-label trial to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses of intrathecally administered VO659 in participants with spinocerebellar ataxia types 1, 3. assessing the safety of this novel Antisense oligonucleotide(ASO) treatment in patients with these rare diseases. He/she will also have the opportunity to participate in current basic and observational research including longitudinal studies of dominant and recessive ataxias and at-risk groups and healthy volunteers to identify reliable biomarkers of disease and develop new therapeutic targets.

The postholder will gain extensive experience in the set up and execution of clinical trials and laboratory based / translational research. They will also be involved in the clinical activity of the Ataxia clinics and the multidisciplinary meeting.

Applicants should have a medical degree and eligible for full registration with the GMC at time of appointment and hold a current licence to practise and have previous experience in neurology, or general medicine and excellent skill in performing lumbar puncture

University College London Hospitals NHS Foundation Trust (UCLH) is one of the most complex NHS trusts in the UK, serving a large and diverse population. We provide academically led acute and specialist services, to people from the local area, from throughout the United Kingdom and overseas. Our vision is to deliver top-quality patient care, excellent education, and world-class research.

We provide first-class acute and specialist services across eight sites:o University College Hospital (incorporating the Elizabeth Garrett Anderson Wing)o National Hospital for Neurology and Neurosurgeryo Royal National ENT and Eastman Dental Hospitalso University College Hospital Grafton Way Buildingo Royal London Hospital for Integrated Medicineo University College Hospital Macmillan Cancer Centreo The Hospital for Tropical Diseaseso University College Hospital at Westmoreland Street

We are dedicated to the diagnosis and treatment of many complex illnesses. UCLH specialises in women's health and the treatment of cancer, infection, neurological, gastrointestinal and oral disease. It has world class support services including critical care, imaging, nuclear medicine and pathology.

We are committed to sustainability and have pledged to become a carbon net zero health service, embedding sustainable practice throughout UCLH. We have set an ambitious target of net zero for our direct emissions by 2031 and indirect emissions by 2040.