Biomedical Scientist

To participate in the provision of a comprehensive diagnostic neuropathology and muscle pathology service to Bristol foundation and to a few external organisations including other healthcare trusts, and some coronial and criminal investigation services. The post-holder will be expected to rotate through the various sections of the Laboratory (biopsy & autopsy, immunohistochemistry; enzyme histochemistry;). The role requires working hours between 9.00am and 5.15pm, with occasional flexibility required to meet service needs. Neuropathology resides within the Cellular Pathology department, and the post may be required to work within Histology increasingly overtime. Appropriate training will be provided to enable post holders to develop the necessary competencies to fulfil the requirements of the role, Paraffin wax histology of surgical biopsies -Assisting a pathologist with specimen cut-upProcessing and embedding specimens into waxMicrotomy of wax blocks using a rotary microtome to produce sections for mounting on slidesStaining of these slides by a range of dye methods to demonstrate specific tissue components Paraffin wax histology of autopsy specimens to include -Processing and embedding large specimens into waxMicrotomy of large dimension wax blocks using a rotary microtome to produce sections for mounting on large format slides o Urgent interoperative diagnostic methods -Staining of biopsy tissue smears for inter-operative diagnosisFreezing and cutting sections of these frozen blocks of biopsy tissue using a cryostat. These sections are mounted on slides and stained. o Enzyme histochemistry of muscle biopsies -Dissection, sampling and rapid freezing of specimens using iso-pentane cooled in liquid nitrogenUsing a cryostat to cut sections of the frozen muscle for mounting on glass slidesPerforming a range of enzyme histochemical incubations on mounted sections of the specimen to demonstrate the pattern of activity of these enzymes in the muscle tissue o Immunohistochemistry - Application of immunohistochemistry techniques to both wax-embedded and frozen tissue samples. Cytology methods -Preparation of slides containing cells extracted from cerebral spinal fluid suspensions using a cytocentrifugation technique;Staining of these slides for microscopy

Bristol NHS Foundation Trust brings together more than 28,000 staff to deliver over 160 clinical services across thirteen hospital locations, operating from three main sites at Southmead, Bristol city centre and Weston. With an annual turnover of 2.6 billion, we are now one of the largest NHS trusts in the United Kingdom. Chaired by Ingrid Barker and led by Maria Kane as Chief Executive, Bristol NHS Foundation Trust aims to transform the way healthcare is delivered locally with a clear focus on making a difference for what we call our Four Ps:

• Better outcomes for ourPatients
• More opportunities for our People
• Fairer more consistent care for ourPopulation
• Best Value for Public Purse
Our vision for five years from now:
• Patients will wait less time to be diagnosed and treated, and they will have the same high-quality experience and outcomes, regardless of who they are or where they live.
• We will meet rising demand by maximising the use of our available resources.
• More care will be delivered nearer to patients, in their homes or the community.
• Digital technologies will have transformed the way we work and the way we deliver care.
• Our people will feel engaged, energised and empowered by their work.
• We will be known as a place where people enjoy working, training and building a career.
• Our volume of globally renowned research and innovation will have grown significantly.
• We will contribute to system financial balance