Artificial Intelligence
Medicines and Healthcare products Regulatory Agency, Ayot Green, Hertfordshire
Artificial Intelligence
Salary not available. View on company website.
Medicines and Healthcare products Regulatory Agency, Ayot Green, Hertfordshire
- Full time
- Temporary
- Onsite working
Posted today, 30 Apr | Get your application in now to be one of the first to apply.
Closing date: Closing date not specified
Job ref: 96b0aa797d5043fdab4e7539d5f3b3e3
Location ref: Ayot Green, Hertfordshire
Full Job Description
- Assay development and immunological evaluation Develop, optimise, and apply serological assays (multiplex Luminex and ELISA) to evaluate human sera from recipients of gonococcal OMV-based vaccines.
- Microbiological culture and OMV production Culture Neisseria species (primarily Neisseria gonorrhoeae), including the isolation, purification, and quality assessment of outer membrane vesicles (OMVs).
- Analytical and proteomic characterisation Perform proteomic analyses to define OMV composition and support vaccine-related research and development activities.
- Scientific collaboration, reporting, and data presentation. Maintain accurate records, contribute to reports, collaborate with internal teams and external partners (UKHSA and GF), and present data at internal and external meetings., We use the Civil Service Success Profiles to assess our candidates, find out more here.
- Online application form, including questions based on the Behaviour, Experience and Technical Success Profiles. Please ensure all application questions are completed in full; your application may not be considered if any responses are left blank. Our applications are CV blind, and our Hiring Managers will not be able to access your CV when reviewing your application.
- Interview, which can include questions based on the Behaviour, Experience, Technical and Strengths Success Profiles. In the instance that we receive a high number of applications, we will hold an initial sift based on the lead criteria of candidates demonstrating Hands-on laboratory skills and assay development experience. Demonstrated experience in laboratory techniques including and the development and optimisation of serological assays (e.g. ELISA, multiplex Luminex). Applicants are assessed on whether they meet any mandatory requirements as well as the necessary skills and experience for the role. Applications are scored based on the competency-based answers provided- ensure you have read these thoroughly and allow sufficient time. You can view the competencies for this role in the job description., Certain roles within the MHRA will require post holders to have vaccinations, and in some circumstances, routine health surveillance. These roles include:
- Laboratory-based roles working directly with known pathogens
- Maintenance roles, particularly those required to work in laboratory settings
- Roles that involve visiting other establishments where vaccination is required
- Roles required to travel overseas where specific vaccination may be required. Applicants who are successful at interview will be, as part of pre-employment screening subject to a check on the Internal Fraud Database (IFD). This check will provide information about employees who have been dismissed for fraud or dishonesty offences. This check also applies to employees who resign or otherwise leave before being dismissed for fraud or dishonesty had their employment continued. Any applicant's details held on the IFD will be refused employment. A candidate is not eligible to apply for a role within the Civil Service if the application is made within a 5 year period following a dismissal for carrying out internal fraud against government. Any move to the MHRA from another employer will mean you can no longer access childcare vouchers. This includes moves between government departments. You may however be eligible for other government schemes, including Tax-Free Childcare. Determine your eligibility here. Individuals appointed on level transfer will retain their existing salary and are responsible for ensuring they fully understand the financial implications of any potential move and the impact (if any) on their terms. If an individual is in any doubt, they should seek clarification before accepting a job offer. Staff joining on promotion will receive up to a 10% increase of their current basic salary, or the pay band minimum, whichever is the greater. The individual will not retain any allowances paid by the former department/Agency, unless there are special circumstances, such as a reserved right to those allowances on transfer.
- Technical - Good analytical and data management skills with the ability to interpret complex data sets (A,I)
- Technical - An understanding of vaccine development and serological assays used in evaluation of post-immunisation serum (A,I)
- Experience- Hands-on laboratory skills using immunoassays and working with CL2 pathogen (A,I) Demonstrated experience in laboratory techniques such as ELISA and Luminex etc. Experience working with CL2 pathogens
- Experience. Practical experience running immunological, functional or cell-based assays which can be used to evaluate vaccine induced response. Experience of assay qualification and validation is desirable.
- Behaviour- Making Effective Decisions (A, I) Ability to analyse, interpret, and critically evaluate experimental data, with experience in presenting clear, robust conclusions to support scientific decision-making.
- Communicating and Influencing: Communicate in a straightforward, honest and engaging manner, choosing appropriate styles to maximise understanding and impact. Share information as appropriate and check understanding
- Behaviour- Working Together (A, I) Confidence in working collaboratively with internal teams and external partners (e.g. public health or academic stakeholders), and in presenting scientific data at meetings and conferences to both specialist and non-specialist audiences., Candidates will be subject to UK immigration requirements as well as Civil Service nationality rules. Further information on whether you are able to apply is available here. Successful candidates must pass a disclosure and barring security check as well as animal rights and pro-life activism checks. People working with government assets must complete basic personnel security standard checks.
A degree (or equivalent experience) in microbiology, immunology, biochemistry, or a related life science, with practical experience in bacterial culture - ideally including Neisseria species and/or vaccine-related research.
The Medicines and Healthcare products Regulatory Agency enhance and improve the health of millions of people every day through the effective regulation of medicines and medical devices, underpinned by science and research. The Science and Research Group delivers public health impact through four subgroups: Control Testing, Research and Development, Standards Lifecycle, and Health & Safety and Quality Assurance, working together to ensure quality, drive innovation, and improve health outcomes. The Research and Development group deliver applied regulatory research developing novel assays and reference reagents to ensure the quality and safety of biological medicines. The Research & Development function provides scientific expertise to support the regulation of vaccines. Through applied research, method development, and collaboration with national and international partners, the function generates robust scientific evidence to support regulatory decision-making, and timely access to safe and effective vaccines. What's the role? This is an 18-month fixed-term project funded by the Gates Foundation (GF). The project is a collaboration between MHRA and UKHSA. Gonococcal outer membrane vesicles will be produced at industrial scale by UKHSA. These samples will then be analysed using proteomic approaches to characterise their protein composition by mass spectrometry, and to develop a multiplex IgG-binding immunoassay at MHRA.
Direct job link
https://www.jobs24.co.uk/job/artificial-intelligence-126766579