Associate Principal Scientist- Protein Engineering and Novel Modalities

Are you ready to take a crucial inter-disciplinary approach to deliver life-changing medicines? We are seeking a highly motivated Associate Principal Scientist to help support our Respiratory and Immunology discovery pipeline. Leading from the bench, the role will involve developing and implementing our next-generation modalities in their application to pre-clinical programs., As an Associate Principal Scientist, you will bring your expertise in multivalent molecular design to the table. Your strong experience in the application of protein, molecular biology and/or biophysical skill sets will be crucial in creating and characterising the next generation of biologics, with a focus on multi-specific molecules and cellular engagers. You will execute experiments efficiently, analyse, interpret, and present data and ideas to a wider audience.,

• A Ph.D level scientist with significant post-doctoral experience, or Batchelor's degree with significant experience in an industry setting


• Deep understanding of antibody structure-function relationships, leading to innovation in the field, as evidenced by publications and/or patents


• Experience in protein design, production and characterisation of antibodies, or antibody-like scaffolds, common expression systems (e.g. mammalian) and purification methods (e.g. Akta systems), and the ability to profile constructs (e.g. SPR; biochemical assays)


• Strong hands-on experience in molecular biology methods and technologies e.g. PCR, RT-PCR, cloning (ligation-dependent and independent methods), site-directed mutagenesis, Sanger sequencing/analysis


• Ability to optimize protocols, troubleshoot, interpret experimental results/data and maintain accurate, high-quality and up-to-date experimental records


• Strong communication skills in a team environment and an ability to quickly learn and adopt new technologies


• Experience leading matrix teams


Desirable Skills/Experience:

• Background in drug discovery and development in the pharmaceutical industry


• Experience in silico design and optimisation of proteins


• Experience in automation


• Line management


When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. The role is lab based, with additional office-based activities, and requires you to be present on-site.

Why AstraZeneca?

We take an inter-disciplinary approach including novel biomarkers, AI, novel endpoints and cutting-edge trial designs to shape the future of our business and therapeutic areas. Our commitment to patients and pioneering spirit are truly embedded and it's what makes our pipeline unique. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. As part of our Respiratory & Immunology team in Biologics Engineering you will be at the forefront of applying novel modalities and using innovative approaches to create new possibilities.

Salary & Benefits Competitive

Introduction to role