Biochemist

Working within our dynamic laboratories based in Oxfordshire, leading a number of key drug discovery projects, our Biochemist will work within a team of skilled and experienced scientists and closely alongside data scientists, machine learning engineers and automation engineers. The role will involve generating exceptional quality mechanistic and profiling data to support various drug discovery efforts using our automated platform, Ulysses®.,

• Planning, developing and executing a wide range of biochemical assays, including HTRF, FP and other fluorescent based assays for compound profiling


• The opportunity to work independently to develop rational experiments and troubleshoot when needed


• Be aware of current developments in literature and contribute pro-actively with ideas and identify opportunities in the workplace for continuous improvements


• Present results to broader project team members to help influence and drive our drug discovery projects


• Complement data streams with cellular functional assays (e.g., compound, biologic or genetic perturbation endpoints such as cell health, signal transduction, etc.,)


• Employ a combination of scientific tools and methodologies in mechanistic biochemistry/enzymology/biophysics including reagent validation, binding and activity assay development, ligand-target mechanism of action studies, and compound profiling.


• Develop and execute target relevant, fit for purpose biochemical/biophysical/enzymatic assays to support hit triage and progression of candidate quality molecules


• Provide enzymology/biophysics expertise to internal programs as well as external collaborations.


• Explore novel technologies


• Lead and interact with cross-functional scientific teams


• Present research activities at internal and external meetings
  
  Ideally we are looking for someone with biochem lab experience and a keen interest in automation, but for the right individual (who has a degree in Biochemistry) we may be able to provide training, so please send us your CV., Masters level scientist with a passion for biochemistry


• High level of lab competency, industry experience a bonus


• A data quality perfectionist, with a flair for both the theoretical and practical


• Confident, curious, driven, self-directed


• A committed team player and effective, professional communicator (written, spoken, visual)


• Will thrive in a fast-paced inclusive and innovative environment


• Must have experience in assay development and ideally some experience in automated liquid handling and/or HTS and automation platforms (a nice to have!)
  
  Arctoris is a drug discovery biotech company enabled by cutting edge technologies. We're growing our team of drug discovery scientists ad innovators. If this is your passion then we would love to hear from you., Arctoris is a tech-enabled biopharma drug discovery company headquartered in Oxford and Boston. Arctoris combines its unique automation platform, Ulysses, with advanced computational approaches and a world-class team of seasoned drug hunters to guide and rapidly progress its wholly owned and partnered drug discovery programs in oncology and neurology. https://www.arctoris.com