Research Associate in Circadian Mechanisms in Cardiometabolic Disease

We are seeking a highly motivated and talented scientist to join our MRC-funded research programme investigating how disruption of the circadian clock impacts energy metabolism and contributes to metabolic disease. You will play a key role in defining how circadian processes in the liver and other tissues regulate lipid metabolism and mitochondrial function, under both normal and perturbed conditions (e.g. dietary or environmental challenges). This exciting project builds on our recent findings (e.g. Downton et al., PNAS; Hayter et al., Nature Communications; West et al., Nature Communications), which demonstrate that circadian disruptioncaused by simulated shift work, diet-induced obesity, or chronic inflammationleads to aberrant liver function and accumulation of harmful lipid species such as ceramides. Working within a vibrant circadian research community in Manchester, you will employ cutting-edge in vivo and in vitro models, advanced physiological phenotyping, and multi-omic and, As this role involves research at a postgraduate level, applicants who are not an EEA national or a national of an exempt country and who will require sponsorship under the Skilled Worker route of the UK Visas and Immigration's (UKVI) Points Based System in order to take up the role, will be required to apply for an Academic Technology Approval Scheme (ATAS) Certificate and will need to obtain this prior to making any official visa application UKVI)

flux metabolomic approaches. You will also collaborate with leading partners at the Universities of Oxford and Aberdeen. You will have a PhD (or near completion) in a relevant biological or biomedical discipline, and bring experience in mammalian physiology, circadian biology, and/or energy metabolism, strong research experience, analytical and communication skills, and enthusiasm for interdisciplinary and collaborative research.

What you will get in return:

• Fantastic market leading Pension scheme
• Excellent employee health and wellbeing services including an Employee Assistance Programme
• Exceptional starting annual leave entitlement, plus bank holidays
• Additional paid closure over the Christmas period
• Local and national discounts at a range of major retailers
As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit. Our University is positive about flexible working you can find out more here Hybrid working arrangements may be considered.